First of all: Looks very clean and well-rounded! graphics, animations, choice of sounds, voica-acting and cartoony humor are top notch! I also like that contrast of the cute, cell-shaded cartoon style, transitiong to that 3D creepy body-horror-ish appeal. Nice touch on the old footage running in Granny's eyes too! Creative way of explaining the mechanics of the game in the tutorial. When touching the red brain cell: "Oh, that memory is gone!"
Fun to play most when having to avoid the red ones and only touching the cyan-blue ones. The only thing I have to criticise is that when the darker blue ones appear and you have to keep knitting them until they're done, it kind of throws me out of the flow of tryng to hit the cyan-blue ones as fast as possible while trying to avoid the red ones. Kind of wish it was only the red and the cyan-blue ones. Then again, I get the point that the blue ones are a challange that you have to be careful once they turn red and you lose a huge amount of points when the player doesn't pay attention.
Overall, awesome work!